Cancer cell’s formation
April 12th, 2008 Guage
The cell from transforms normally for the malignancy has a process, its key is the gene (genetic material DNA) change. Has two kind of theory theories, namely the gene mutation theory and the gene regulation said abnormally.
(1) gene mutation theory: The ionisation radiation and the majority carcinogens may in the animal the induced tumor, simultaneously they to the microorganism and the zooblast also be the effective mutagens, may create the DNA damage and the induced mutation directly. The gene change often causes the chromosome to have a series of changes like to have the break, the flaw, the inversion and so on, these changes and the tumor occur closely related. In the normal condition, the cancer gene and damps the cancer gene the function to be at the state of equilibrium, leads the carcinogenic gene by the sudden change the function enhancement, or, because changes suddenly or the flaw causes to damp the cancer gene deactivation, finally the cancer cell intemperately will multiply forms the tumor.
The tumor virus carries one kind of activation cancer gene, the conformity to the host cell genome team, thus causes the normal cell to transform as the cancer cell.
(2) gene regulation said abnormally: Tumour cell’s malignant characteristic is not decided by the gene structure change, but because gene expression and regulative abnormal result. Sometimes if clinical highly malignant becomes the nerve cytoma to have the nature obviously to abate, splits up the normal ganglion cell. Therefore, under the controlled condition, the tumour cell may appear to the normal cell direction phenotype reversal.
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